Defective Proteasome Delivery of Polyubiquitinated Proteins by Ubiquilin-2 Proteins Containing ALS Mutations.

Ubiquilin proteins facilitate delivery of ubiquitinated proteins to the proteasome for degradation.Interest in the proteins has been heightened by the discovery that gene mutations in UBQLN2 cause dominant inheritance of amyotrophic lateral sclerosis (ALS).However, the mechanisms by which the mutations cause ALS are not crank sleeve known.Here we r

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Exploring the Potential of Olive Flounder Processing By-Products as a Source of Functional Ingredients for Muscle Enhancement

Olive flounder (OF) is a widely aqua-cultivated and recognized socioeconomic resource in Korea.However, more than 50% of by-products are generated when processing one OF, and there is no proper way to Reel-to-Reel Tape Players utilize them.With rising awareness and interest in eco-friendly bio-materialization recycling, this research investigates t

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The Matrons of the Church of Rome in Late Antiquity

In the present work we will present in the ascetic movement in Christianity and the gender relations existing in these religious tendencies in Methionine Late Antiquity.The characteristics and forms of Christian asceticism, sexual renunciation and, finally, women in the Church of Rome in the late fourth century CE.These matrons led a significant mo

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The effects of theta-burst stimulation on vigilance in humans

Repetitive transcranial magnetic stimulation has become a popular tool to modulate neuronal networks and associated brain functions in both clinical and basic research.Yet few studies have examined the potential effects of cortical stimulation on general levels of vigilance.In this exploratory study, we used theta-burst protocols, both continuous (

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